The Use of a Wound Protector as a Self Retaining Skin Retractor for Skin Sparing Mastectomy and Immediate Reconstruction

Peer reviewedPublisher PD

The Changing Face of Emergency General Surgery : A 20-Year Analysis of Secular Trends in Demographics, Diagnoses, Operations and Outcomes

ACKNOWLEDGMENTS The authors thank Dr Neil Scott and Mrs Rute Vieira for their statistical expertise. There were no financial or material contribution from any source for this work. We would also like to thank the Information Services Division of the NHS in Scotland for extracting the data, and the Data Safehaven at the University of Aberdeen for hosting it. This study was funded by NHS Grampian Endowments, Aberdeen, UK. No funding was received from the National Institutes of Health, Wellcome Trust or Howard Hughes Medical InstitutePeer reviewedPublisher PD

A 19 year population based cohort study analysing reoperation for recurrence following laparoscopic and open inguinal hernia repairs

Open Access via Springer Compact Agreement.Peer reviewedPublisher PD

Chronomodulated Administration of Chemotherapy in Advanced Colorectal Cancer : A Systematic Review and Meta-Analysis

We would like to thank Kirsty Morrison, Senior Information Specialist, Royal College of Surgeons of England Library and Archives Team, for conducting the literature searches. The datasets generated during and/or analysed during the current study are available in the [SoF copy2.xlsx] and [chronomodulation.rm5] at: https://1drv.ms/u/s!AlzdopwEri123kc7F0pt4YnN8drW?e=lylmBq. AN contributed to abstract screening, full-text review, data extraction, analysis, designing, and writing of the manuscript. AA contributed to abstract screening, full-text review, and data extraction. GR contributed to a substantive and major revision of the draft. MB contributed to conceptualisation, resolution of conflicts during abstract screening and full-text review, and major revision of the draft and is the corresponding author. All authors approved the final version prior to submission.Peer reviewedPublisher PD

Prognostic Value of Computed Tomography : Measured Parameters of Body Composition in Primary Operable Gastrointestinal Cancers

Professor Graeme Murray, Department of Pathology, University of Aberdeen provided us access to the colorectal cancer pathology databases from which the colorectal component of the research was based. Conflict of interest There are no conflicts of interest.Peer reviewedPublisher PD

Studies on the control of respiration

Abstract Not Provided

Current and projected financial burden of emergency general surgery for adults in Scotland’s single payer healthcare system : a cost analysis of hospital admissions

No funding received, including none from National Institutes of Health, Wellcome Trust or Howard Hughes Medical Institute. The authors report no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.annalsofsurgery.com).Peer reviewedPostprintPostprin

Impact of deprivation and comorbidity on outcomes in emergency general surgery : an epidemiological study

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.Peer reviewedPublisher PD

Molecular genetic and physical analysis of gas vesicles in buoyant enterobacteria.

Different modes of bacterial taxis play important roles in environmental adaptation, survival, colonization and dissemination of disease. One mode of taxis is flotation due to the production of gas vesicles. Gas vesicles are proteinaceous intracellular organelles, permeable only to gas, that enable flotation in aquatic niches. Gene clusters for gas vesicle biosynthesis are partially conserved in various archaea, cyanobacteria, and some proteobacteria, such as the enterobacterium, Serratia sp. ATCC 39006 (S39006). Here we present the first systematic analysis of the genes required to produce gas vesicles in S39006, identifying how this differs from the archaeon Halobacterium salinarum. We define 11 proteins essential for gas vesicle production. Mutation of gvpN or gvpV produced small bicone gas vesicles, suggesting that the cognate proteins are involved in the morphogenetic assembly pathway from bicones to mature cylindrical forms. Using volumetric compression, gas vesicles were shown to comprise 17% of S39006 cells, whereas in Escherichia coli heterologously expressing the gas vesicle cluster in a deregulated environment, gas vesicles can occupy around half of cellular volume. Gas vesicle production in S39006 and E. coli was exploited to calculate the instantaneous turgor pressure within cultured bacterial cells; the first time this has been performed in either strain.The authors would like to thank Professor Tony Walsby (Emeritus, Bristol university) for advice, technical help and donation of the pressure nephelometry and volumetric calculation apparatus. We would also like to thank Alison Drew for technical support and Chin Mei Lee and Andrew Day for critical reading. REM and GPCS were supported through the BBSRC (Grant ID BB/K001833/1). YT was supported by a Scientific Research Fellowship from the Japan Society for the Promotion of Sciences (JSPS) and JPR was supported by a Herschel Smith Post Doctoral Fellowship while at Cambridge University.This is the final version of the article. It first appeared from Wiley via https://doi.org/10.1111/1462-2920.1320